Objective:To investigate the effect of disoprofol target controlled infusion for bronchoalveolar lavage in critical patients be treated by mechanical ventilation.Methods:61 cases in ICU

who were treated by mechanical ventilation

were randomly divided into 2 groups:disoprofol group(A-group)and diazepam combined with midazolam group(B-group)

monitoring and recording electrocardiogram wave form

breathing

SPO2 and blood pressure from preoperative 10 minutes to postoperative before Ramsay≤Ⅱ.Recording the time of bronchoalveolar lavage and postoperative before Ramsay≤Ⅱ

also the Patients’performance and subjective memory in the process of BAL after operation in 30 min.Results:HR and Br of A-group were much lower than B-group after operation 10 min.The restlessness

nausea

vomiting

choke cough adverse reaction rate of A-group were less than B-group during the operation.The time of BAL in A-group was shorter than B-group.A-group of awakening is faster than B-group.Surgery and painful memories in A-group were less than B-group. When propofol target control induction dose

HR

Br and SBP of A-group were much lower than B-group.Conclusion:Propofol target controlled infusion can effectively improve the stress state of patients who treated by mechanical ventilation

reducing the related side effects of BAL

such as restless

nausea and vomiting

awakening fast after operation

no pain memories

which is a good way of calm when the patients need interventional operation in Intensive Care Unit.