Objective:To observe the therapeutic effects and side effects of FAT (fludarabine

cytarabin

and topotecan)regimen for relapsed or refractory acute leukemia.Methods:The regiment consisted of Flu 25 mg/ (m2·d)iv 30 min

from dl to d5;Ara-C 1.0 or 2 g/ (m2·d)iv 4 h

from dl to d5

and Top 1.2 mg/(m2·d)iv 2h

form d1 to d3. G-CSF was to employ from WBC<1.0×109/L until the WBC> 4×109/L .9 cases of refractory or relapsed acute leukemia were treated with this regimen.Results:In all the 9 cases of leukemia

6 cases achieved the complete remission (6/9)

1 case had achieved partly remission and 2 cases had no response .The main toxicities were myelosupression

fever

diarrhea and slight hepatic injury .Conclusion:FAT regiment shows favorable outcome for refractory or relapsed acute leukemia

and side effects can be tolerance .It can be employed for the patients with refractory or relapsed acute leukemia who had no response to the first line regimen or other salvage regimens and get a chance for further hematopoietic stem cell transplantation.