Objective:The methods of hormone therapy prompt us to renewedly handle the perimenopausal dysfunctional uterine bleeding (DUB) and postmenopausal vaginal bleeding

search dangerous factors and optimize therapeutic schemes in order to reduce non-essential diagnostic curettage. Methods:45 perimenopausal women and 182 menopausal ones were choosed in our research and the following each index including the age of onset

body mass index

the course of diseases

excessive mentses

hypertension

diabetes

hormone replacement therapy

postoperative application of breast cancer

hypothyroidism

polycystic ovary syndrome or endometrial thickness was set as a variable to sdtudy the relationship between each variable and endometrial abnormity using Logistic regression analysis. Results:According to the Logistic regression analysis

there was a relevance between endometrial thickness and endometrial abnormity(endometrial hyperplasia & endometrial cancer)when the endometrial thickness was equal to or more than 7 mm during the perimenopause period (P=0.02)

and so it was with the menopausal period when the endometrial thickness was equal to or more than 9 mm (P<0.009).Other factors had no significant influences on the endometrial abnormity. Conclusion:Diagnostic curettage is non-essential when endometrial thickness is less than 5 mm during the menopausal period

especially when it is less than 7 mm during the perimenopausal period.Once the endometrial thickness is less than 9 mm

regular hormone therapy can be firstly adopted. If the hormone therapy is ineffective

diagnostic curettage will be adopted. The study showed that about one third of patients were exempted from the pain caused by uterine curettage.