Objective:To evaluate the clinical significance for determination of vascular endothelial growth factor in patients with acute coronary syndrome.Methods:In our hospital from January 2006 to December 2008

78 cases of acute coronary syndrome were selected.Using double-antibody sandwich enzyme-linked immunosorbent assay for determination of vascular endothelial growth factor concentration

as well as coronary angiography in parallel to assess the situation of coronary stenosis.Follow-up 90d

major cardiovascular adverse events recorded.Results:In the four groups of no significant coronary artery stenosis

stenosis ≤ 50%

and stenosis 50% to 80%

and stenosis> 80%

there are differences of VEGF concentration(χ2= 13.547

P= 0.000 1)

VEGF concentration was significantly higher in the group of stenosis 50% to 80% and the group stenosis> 80%.90d follow-up of 78 cases of heart patients with iatrogenic one cases of sudden cardiac death

5 cases of non-fatal myocardial infarction

11 cases of refractory angina pectoris

revascularization

as well as 12 cases of stent implantation.VEGF level is the major cardiovascular adverse events have an independent risk factor

OR value 1.017

95% CI as 1.011～1.023.Conclusion:The vascular endothelial growth factor concentrations related to coronary stenosis and the rate of major cardiovascular-related adverse events in patients with acute coronary syndrome

monitoring the concentration of vascular endothelial growth factor has important clinical significance.