Objective:To study the role of selective psychological intervention on peripheral blood cytokine(interleukin-2

interleukin-4

tumor necrosis factor-γ)(IL-2

IL-4

TNF-γ)and unhealthy emotion in patients with chemotherapeutical breast cance.Methods:Randomized-control study method was adopted.Eighty chemotherapeutical inpatients with breast cancer were divided into intervention group and control group(40 patients in each group).Patients in both groups received mutine chemotherapy and health education

while the intervention group also received selective psychological intervention.The psychological and behavior rating were observated with Zung anxiety scale(SAS)/Zung depression scale(SDS)and symptom checklist(SCL-90)pre-and three month post-chemotherapy.Psychological intervention methods were selected independently and completed by patients.The effect of selective psychological intervention on unhealthy emotions were observed in breast cancer inpatients undergoing chemotherapeutics.The changes of IL-2/IL-4/TNF-γin peripheral blood were detemined by radioimmunity.Results:The breast cancer inpatients in both groups were noticeably depressed after chemotherapy(P<0.05).In contrast to control group

the unhealthy emotions of breast cancer inpatients with selective psychological intervention were obvious depression after chemotherapy(P<0.05)(.these two sentences are not clear in meaning.Rewrite them)After chemotherapy

the IL-2/IL-4 were increased obviously with selective psychological intervention as compared with the control group(P<0.05)

the TNF-γwas increased too

but showing no statistical difference(P>0.05).Conclusion:The selective psychological intervention could inhibit the unhealthy emotion of breast cancer patients undergoing chemotherapy and increase the content of some cytokines in peripheral blood

which may be related with immunity enhancement.