Objective:To set up the rat model ofchronic intermittent hypoxia under normal pressure and studyits effect on the level of blood glucose and pancreatic islet B-cells

ultrstructure.Methods:Rats were respectively exposed to room air 4 weeks(unhandled control

UC)

intermittent hypoxia 4 weeks(chronic intermittent hypoxia

CIH)

intermittent hypoxia 4 weeks and then room air 4 weeks(restore hypoxia

RH).To test the fasting blood glucose of rats in each group

the fasting blood insulin and C-peptid

and then get the insulin resistance index

and observe the pancreatic islet B-cells under transmission electron microscope.Results:The level of blood glucose of the rats in the CIH group increased significantly compared with those in the UC group and RH group.There was insulin resistance and slight alteration of pancreatic islet B-cells in the CIH group

but there was no difference between UC group and RH group.Conclusion:Chronic intermittent hypoxia can lead to the pancreatic islet B-cell damage and its function disturbance

There was also insulin resistance

which causes the increased level of blood glucose of the rats in the CIH group to increase.