Objective:To assess if the ratio of ApoB/ApoA1 is related to insulin resistance.Methods:673 adults living in Chongqing were enrolled.Weight

height

blood pressure

waist circumferences

fasting plasma glucose(FPG)

fasting serum insulin(FINS)and lipids were measured.ApoB/ApoA1 ratio

BMI and insulin resistance index(Homa-IR)were calculated.Subjects were divided into four groups according to the quartiles of ApoB/ApoA1 ratio.Logistic regression was used to estimate the relation between ApoB/ApoA1 ratio and insulin resistance.Results:Compared with the non-insulin resistant group

the insulin resistant group is older and has on average greater mean values for BMI

systolic and diastolic blood pressure

fasting plasma glucose

triglycerides

LDL-cholesterol

and ApoB/ApoA1 ratio.In contrast

insulin resistant subjects has significantly lower HDL-cholesterol than insulin sensitive subjects(P<0.05).Homeostasis model assessment increased significantly as ApoB/ApoA1 ratio increased(P<0.001).Compared with the lowest quartile of ApoB/ApoA1 ratio

the highest quartile of ApoB/ApoA1 ratio is more likely to get IR

and the risk increased 2.586 times(P=0.001).Conclusion:ApoB/ApoA1 ratio is strongly associated with insulin resistance(IR)

and a high ApoB/ApoA1 ratio is a valuable marker of IR.