Objective:To investigate the clinical efficacy between one and two hemoperfusion in treatment of chronic hepatitis with hyperbilirubinemia.Methods:The clinical data of 68 chronic hepatitis patients with hyperbilirubinemia were reviewed restropectively.27 patients were treated with one hemoperfusion(HP1)and 41 patients were treated with two hemoperfusion(HP2).The liver function

prothrombin time activity

biochemical indicators before and after hemoperfusion in the two groups were compared and analyzed.Results:After two hemoperfusion treatment.

Compared with HP1

the levels of bilirubin and transaminase were decreased significantly(P<0.05)but the erythrocyte and hemoglobin were also decreased significantly(P<0.05)in HP2 treatment group(434.44± 163.28)v(s480.48±168.31)

(104.85±142.85)v(s176.77±132.61)

(3.30±0.58)v(s3.58±0.48)

(95.49±15.31)v(s108.93± 15.66)

other indicators had no significanc(P>0.05).Conclusions:Two hemoperfusion treatment can more effectively make bilirubin and transaminase removed from patients of chronic hepatitis with hyperbilirubinemia

so two hemoperfusion was safe and effective treatment for patients with hyperbilirubinemia.