Objective:Assessment ofthe value of B-type natriuretic peptide levels combines TIMI risk scores in predictinglate mortality in patients with ST-segment Elevation Myocardial Infarction(STEMI).Methods:345 patients with STEMI were studied.Blood was drawn and the plasma concentration of BNP was determined within 24 hours after the onset of chest pain and the patients’TIMI risk score was measured.The all-cause mortality

including cardiac and non-cardiac deaths during Long-term follow-up

was recorded.Results:Mortality was 20.0%(n=69)during a follow-up of 314±208 days.The late mortality was related to higher TIMI risk scores(P<0.001).Higher BNP levels were also related to increased late mortality(median(range)ng/L

survivors 447.5(8～2 854)vs dead 986.0(31～4 986)

P<0.001).In a multivariate Cox proportional hazards model

independent predictors of late mortality were BNP levels in the first 24 hours(BNP

2.608(95%CI

1.840～3.696)>;P<0.001)and TIMI risk scores(1.227(95%CI

1.138～1.323)

P<0.001).The Kaplan-Meier survival curve showed a significantly better clinical outcome in patients with BNP belowthe median than in those with BNP above the median(P<0.001).BNP yielded an area under the curve(AUC)of 0.797(P<0.001)

for TIMI risk score the AUC was 0.780(P<0.001)

for the AUC of combination of TIMI score and BNP was 0.853(P<0.001).Conclusion:In the first 24 hours following an STEMI

BNP and TIMI risk score can predict late mortality reliably.The combination of TIMI score and BNP can improve risk prediction for mortality.