Objective:To explore the radioprotective effect of TFA on the 60Coγ-rayirradiated mice and provide an experimental basis for the clinical use of TFA.Methods:Normal female Kunming mice were intragastrically administered with TFA for 3days before exposure to lethal dose of 60Coγ-ray radiation and then continuously administered with TFA for 11days.The 30-days survival rate and average life span of irradiated mice were estimated.Meanwhile the body weight

peripheral blood parameters

spleen indexes and the pathological changes of spleen were also observed in the sublethal dose irradiated mice.Results:TFA could not only increase the 30-days survival rate and the average survival days of dead mice(P<0.05)

but also could cut down significantly the descent extent of the peripheral blood WBC numbers and shorten the time of WBC restoration rapidly inγ-ray irradiated mice(P<0.05).Furthermore TFA could also promote the recovery of spleen index

decrease the damage ofγ-ray on the spleen and promote the growth of hematopoietic cells and blood-producing function.Conclusion:TFA has significant anti-radiation effect and can effectively raise the survival rate of mice irradiated with a lethal dose of 60Coγ-rays.It can also reduce the radiation injury of WBC and PLT as well as spleen in irradiated mice.