抗肝纤维化姜黄素脂质体的制备及初步稳定性考察

赵怡; 孟路华; 潘黎军; 王驰

doi:10.13406/j.cnki.cyxb.2010.04.001

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抗肝纤维化姜黄素脂质体的制备及初步稳定性考察

技术与方法 | 更新时间：2024-01-17

- 抗肝纤维化姜黄素脂质体的制备及初步稳定性考察
- Preparation of curcumin liposome and preliminary study on its stability
- 重庆医科大学学报 2010年35卷第4期页码：582-585
- 作者机构：
  
  重庆医科大学药学院药物化学教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.04.001
  中图分类号： TQ464
- 纸质出版日期：2010，
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[1]赵怡,孟路华,潘黎军,王驰.抗肝纤维化姜黄素脂质体的制备及初步稳定性考察[J].重庆医科大学学报,2010,35(04):582-585.

ZHAO Yi, et al. Preparation of curcumin liposome and preliminary study on its stability[J]. Journal of Chongqing Medical University, 2010,35(4):582-585.
[1]赵怡,孟路华,潘黎军,王驰.抗肝纤维化姜黄素脂质体的制备及初步稳定性考察[J].重庆医科大学学报,2010,35(04):582-585. DOI： 10.13406/j.cnki.cyxb.2010.04.001.

ZHAO Yi, et al. Preparation of curcumin liposome and preliminary study on its stability[J]. Journal of Chongqing Medical University, 2010,35(4):582-585. DOI： 10.13406/j.cnki.cyxb.2010.04.001.

摘要

目的:制备姜黄素（Curcumin

Cur）脂质体并考察其包封率及稳定性。方法:采用逆相蒸发法制备Cur脂质体

葡聚糖凝胶柱层析法分离含药脂质体与游离药物并测定包封率;正交设计优选制备处方;离心加速实验与渗漏率的测定考察脂质体的稳定性。结果:所得优化处方为磷脂与药物的重量比60:1

磷脂与胆固醇的重量比4:1

pH6.5的磷酸盐缓冲液水合递质

超声时间为5min。以优化处方制得的脂质体平均包封率达95.06%。结论:选用逆相蒸发法优化Cur脂质体处方合理

工艺简便可行

包封率高

稳定性好。

Abstract

Objective:To prepare curcumin liposome and investigate its stability.Methods:Curcumin liposome was prepared by the reversed-phase evaporation method and purified by exclusion chromatography with Sephadex-50.The optimum formation was selected by means of orthogonal design of experiment;Centrifugal acceleration experiment and determination of leakling ration were served to proved the liposome stability.Results:The optimum formula was as follows:the ratio of lecithin to drug was 60∶1;lecithin:cholesterol was 4∶1;pH of PBS was 6.5

ultrasonic time was 5min.The average entrapment efficiency for curcumin was 95.06%.Conclusion:The selected formulation and preparation technique of curcumin liposome is reasonable in prescription

practicable in techniques

high in encapsulation efficiency and good in stability.

关键词

姜黄素脂质体逆相蒸发法正交设计包封率稳定性

Keywords

Curcumin liposomeReverse phase evaporationorthogonal designencapsulation efficiencystability

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