Objective:To compare the characteristics of allergic rhinitis animal models in two different animals(Guinea pigs and New Zealand rabbits) induced with various doses of toluene-2

4-Diisocyanate(TDI).Methods:Low dose and high dose of TDI olive oil solution was used as sensitizer to establish models of Guinea pigs and New Zealand rabbits.The typical symptoms and sings of Guinea pigs and New Zealand rabbits were respectively scored during modeling.After the last challenge

nasal mucosa of Guinea pigs and New Zealand rabbits were histopathologically examined and the level of histamine in nasal mucosa was measured by spectrofluorometer.The mortality rates and model success rates were record.Respiratory tracts of dead animals were dissected and histopathologically examined to find out the causes of their death.Results:Compared with control groups

all the Guinea pigs and New Zealand rabbits in model groups got typical symptoms and sings of allergic rhinitis.Histopathology examination of nasal mucosa showed eosinophile cells infiltrating obviously.The levels of histamine in nasal mucosa were highly increased(P<0.01).However

between Guinea pigs and New Zealand rabbits

even the same animal specie but treated with different doses of TDI demonstrated obviously different results during modeling

including the time of symptoms and signs to appear

the most typical symptoms and signs

the degree of invasion of eosinophile cells

the level of histamine in nasal mucosa

the mortality rates and success rates.Dissection of the dead animals shows the cause of death may be connected with the drug doses and allergy.Conclusion:Allergic rhinitis animal models induced with two different doses of TDI in different animals have different characteristics.The selection of animal models should adapt to research purposes.