Objective:To investigate the IL-2 and IL-10 changes impact of treatment outcome in Graves disease(GD).Methods:From January 2007 to December 2008

72 cases of patients with GD in our hospital were detected IL-2 and IL-10 and thyroid hormone levels before and after treatment respectively

the relationship between the IL-2 and IL-10 level with prognosis was evaluated.Results:There are 21 cases of GD in patients with uncontrolled hyperthyroidism

35 cases with hyperthyroidism control

16 cases of early-onset hypothyroidism.The level of IL-2 in uncontrolled hyperthyroidism were the highest

followed by hyperthyroidism control

and in early-onset hypothyroidism were the lowest(P <0.05);IL-10 levels into the trend of anti-change(P<0.05).After treatment

IL-2 increased in uncontrolled hyperthyroidism

in hyperthyroidism control

IL-2 was essentially the same

and in early-onset hypothyroidism

IL-2 decreased(P <0.05);IL-10 levels into the anti-change(P <0.05).IL-2/IL-10 was highest level in uncontrolled hyperthyroidism

followed by hyperthyroidism control

and in early-onset hypothyroidism was the lowest(P<0.05);and the level of IL-2/IL-10 was the same before and after treatment(P>0.05).Conclusion:The higher IL-2/IL-10 ratio shows more difficult for control hyperthyroidism

the lower IL-2/IL-10 ratio shows more easy to produce hypothyroidism;IL-2/IL-10 is a good predictor for GD treatment outcome.