脂质体携载前列腺素E1对冠脉介入治疗后炎症因子的影响

梁文华; 丁继军; 林飞; 唐亮; 李解贵; 彭寒林; 周炜

doi:10.13406/j.cnki.cyxb.2010.03.012

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脂质体携载前列腺素E1对冠脉介入治疗后炎症因子的影响

临床研究 | 更新时间：2024-01-17

- 脂质体携载前列腺素E1对冠脉介入治疗后炎症因子的影响
- Liposomal prostaglandin E1 can reduce inflammatory factors and the incidence of adverse cardiac events for percutaneous coronary intervention
- 重庆医科大学学报 2010年35卷第3期页码：427-429
- 作者机构：
  
  1. 湖南省衡阳市解放军第169医院内三科
  2. 张家港奥洋医院心内科
  3. 第二军医大学附属长海医院
  4. 中南大学湘雅二医院心内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.03.012
  中图分类号： R541.4
- 纸质出版日期：2010，
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[1]梁文华,丁继军,林飞,唐亮,李解贵,彭寒林,周炜.脂质体携载前列腺素E1对冠脉介入治疗后炎症因子的影响[J].重庆医科大学学报,2010,35(03):427-429.

LIANG Wen-hua, et al. Liposomal prostaglandin E1 can reduce inflammatory factors and the incidence of adverse cardiac events for percutaneous coronary intervention[J]. Journal of Chongqing Medical University, 2010,35(3):427-429.
[1]梁文华,丁继军,林飞,唐亮,李解贵,彭寒林,周炜.脂质体携载前列腺素E1对冠脉介入治疗后炎症因子的影响[J].重庆医科大学学报,2010,35(03):427-429. DOI： 10.13406/j.cnki.cyxb.2010.03.012.

LIANG Wen-hua, et al. Liposomal prostaglandin E1 can reduce inflammatory factors and the incidence of adverse cardiac events for percutaneous coronary intervention[J]. Journal of Chongqing Medical University, 2010,35(3):427-429. DOI： 10.13406/j.cnki.cyxb.2010.03.012.

摘要

目的:观察早期使用脂质载体前列腺素E1对经皮冠状动脉介入治疗（Percutaneous coronary intervention

PCI）患者血浆炎症因子的影响。方法:74例行PCI治疗的患者随机分成实验组和对照组。前者入选后给予PGE120μg+生理盐水40ml静脉注射

Bid×3d

对照组患者则不给。其余基础治疗措施相同。于PCI术前1d、术后2d、术后5d、术后4周查CRP、IL-6、TNF-α

并观察观察术后60d内早期心脏事件发生情况。结果:两组患者经PCI治疗后1d

CRP水平有所上升

与同组术前1d相比有显著差异（P<0.05）

但与对照组相比均未见有差异（P>0.05）。术后5d～4周

实验组的水平已较术前有所下降（P<0.05）

对照组较术前亦有下降（P<0.05）

并且实验组CRP的水平较对照组下降更为明显（P>0.05）。炎症因子IL-6、TNF-α和CRP表现出一样的变化趋势。并且

用药期间2组未出现不良反应

安全性良好。结论:在PCI术后早期CRP、IL-6和TNF-α可有升高

但早期应用Lipo-PGE1后

可有效抑制炎症因子水平。

Abstract

Objective:To observe the inflammatory factors for early use of lipid carriers prostaglandin E1 on percutaneous coronary intervention(PCI).Method:74 patients treated with PCI were randomly divided into experimental and control groups.PGE1 20μg + 40 ml normal saline intravenously

Bid × 3 d

were used in experimental groups

but not to the patients in the control group.The basis treatment was the same.CRP

IL-6

TNF-α were checked in the pre-operative 1 d

after 2 d

after 5 d

after 4 w

and after 60 d

the early incidence of cardiac events were observed.Results:CRP levels in every patients for two groups increased at 1 d(P<0.05)

CRP level in the experimental group compared with the control group were not different(P>0.05).After 5 d～4 w

CRP level in the experimental group were declined than 1 d(P <0.05)

also dropped than the control group(P <0.05)

and the level of CRP in the experimental group decreased more than the control group(P>0.05).Inflammatory factor IL-6

TNF-α and CRP showed the same trend.Conclusions:CRP

IL-6 and TNF-α may have increased in the early stage of post-PCI

and the use of Lipo-PGE1 may be effective in containing the level of inflammatory factors.

关键词

前列腺素E1皮冠状动脉介入治疗炎症因子

Keywords

Prostaglandin E1Percutaneous coronary interventioninflammatory factor

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