Objective:To compare the efficacy

security and tolerance of COAPROVEL(150mg Irbesartan and 12.5mg Hydrochlorothia zide per tablet) and HYZAAR(150mg Losartan and 12.5mg Hydrochlorothiazide per tablet)for primary hypertension.Methods:A total of 48 primary hypertensive patients of signed informed consent were enrolled

and required to stop all antihypertensive and vasoactive drugs.Their average systolic blood pressure(SBP) was between 140 ～180mmHg and average diastolic blood pressure(DBP) between 95 ～ 115mmHg by three times’ detection of sitting posture.According to the order which patients were brought into groups patients were randomized

COAPROVEL group and HYZAAR group

each with 24 persons.Those in the treatment group were given one tablet of COAPROVEL for 4 wk at 7am to 8am in the morning

while others were given one tablet of HYZAAR as the control group.Blood pressure

heart rate

liver function

renal function

glucose

lipids and electrolyte were observed before and after treatment and adverse effect incidence rate of the medicine was also observed.Results:BP declined significantly in both groups at 2 wk and 4 wk of drug aministration treatment(P<0.01

P<0.05).Efficacies in COAPROVEL group at 2 wk and 4 wk were respectively higher than those in HYZAAR group(P<0.05).SBP and DBP in COAPROVEL group at 2 wk and 4 wk decreased more than those in HYZAAR group(P<0.05).There were no significant differences of heart rate and biochemical indicators in two groups before and after treatment(P>0.05).Contemporarily

no prominent side effects were found in two groups.Conclusion:Both COAPROVEL and HYZAAR are effectively antihypertensive.COAPROVEL provides greater decline of blood pressure with the same security and tolerance than with HYZAAR.