Objective:To investigate the relationship between aging

gender and coronary heart disease(CHD) in the elderly and very elderly.Methods:A total of 733 consecutive patients underwent Judkins of coronary angiography for enrolled in this study from April 2002 to Dec.2007.Age and clinical characteristics of non-coronary heart disease group(n=306)

single-vessel group(n=211)

double-(n=126) and multi-Vessel group(n=90) were compared referred for angiography.Quantitative comparison of age and risk factors were made among patients with 4 ranges of Gensini’s score corresponding to quartile cut points.The impact of age

gender on CHD was analyzed in four age groups:<60-year-old group(n=116)

60 to 69-year-old group(n=200)

70 to 79-year-old group(n=315)

80-year-old to 89-year-old group(n=102)

multiple regression analysis was performed to identify the association between Gensini’s score and age and risk factors.Results:The CHD incidence of <60-year-old group

60 to 69-year-old group

70 to 79-year-old group and 80-year-old to 89-year-old group was 47.41%

50.50%

64.40% and 68.30% respectively

and for each 10-year-old increase in the elderly ≥60 years old

the risk of having CHD increase by 12.70%

24.20% and 31.70%.Throughout all age groups in this study

men have a higher incidence than female

the male to female risk ratio of CHD was 1.39(P <0.01).Age(P <0.01

P <0.01)

fibrinogen(FIB

P <0.05

P <0.01)

urea nitrogen(Bun

P<0.05

P <0.05

P <0.05)

creatinine(Cr

P <0.01

P <0.01

P <0.01) increased significantly accompanied by the progression of coronary atherosclerosis and Gensini Score.Multiple regression analysis showed that

Bun

Cr and FIB are independent risk factors of Gensini Score.Conclusions:Aging and male was important risk factors of progression of coronary atherosclerosis.