Objective:This study was aimed to analyze the allergen sensitization changes of Skin Prick Tests(SPT)in Children who met the following criteria:diagnosed with asthma

sensitized to House Dust Mite(HDM)or HDM in combination with other allergens and accepting standard HDM specific immunotherapy(SIT).Methods:140 patients were recruited in this study.SPT was performed with a panel of allergens including HDM

cockroach

cat hair

dog hair

moulds

and pollens and we compared the SPT allergen sensitization results of pre-treatment and post-treatment.Results:Of the all 140 patients

72.86%(103/140)was HDM-monosensitized

62.85%was sensitized to HDM in combination with other allergens.SPT was reperformed in 93 of these patients which were treated by SIT for 6 months

and compared with the pre-SIT results

the SPT wheal diameters of all allergens were significantly decreased(P<0.000 1)

except cat hair (P>0.05)and pollen(P>0.05)

and in 78 patients with 12-month SIT treatment

the SPT wheal diameters of all allergens were significantly decreased(p<0.000 1)

cockroach(P<0.005)and pollen(P<0.005).After 6-month or 12-month standard HDM SIT treatment

more than 70%of theses children sensitized to HDM in combination with other allergens were desensitized to the other allergens. After 6-month or 12-month of HDM SIT treatment

there were 84.95%and 87.18%patients showing no new sensitization.Conclusion:SPT allergen sensitization results could be well improved by the treatment of standard HDM SIT

the effectiveness of which is time-and dose-dependent.It is possible that children with multi-allergen sensitization could be desensitisized by a single allergen extraction SIT:HDM SIT has the potential to prevent the onset of new sensitizations in children with rhinitis and/or asthma.