Objective:To investigate the effects of Danhong Injection on expression of ICAM-1 in rat kidneys with ischemia reperfusion (I/R)injury after kidney transplantation.Methods:Ten normal SD rats were allocated into the sham operation.And the rats were only anesthetized

and kidneys were exposed for 45 minutes.The allogeneic male SD rats model of kidney transplantation were established.The recipients were divided into 3 groups(n = 10

in each)at random:I/Rgroup

Danhong pretreatment group

danhong treatment group. B 1 ood urea nitrogen(BUN)and serum creatinine(CR)levels were determined after 24 hours.The expression of ICAM-1 in kidney was quantitatively detected by immunohistochemistry.Results:Compared with those in the Sham group

the expression of ICAM-1(P<0.01) and the Paller’s grades of kidney tubule(P<0.01)in I/R model group and Danhong treatment group were significantly increased.The kidney tubular epithelial cells distributed disorderly.The necrosis and pyknosis of kidney tubular epithelial cells increased very much with inflammatory cell infiltration.The kidney tubular Paller’ s grades were positively related with the expression of ICAM-1(r=0.92

P<0.05). By Danhong pretreatment

the expression of ICAM-1 and the Paller’s grades of kindey tubule(P<0.01)were decreased significantly(P<0.01). The kindey tubules epithelial cells swelled mildly.The inflammatory cell infiltration was obviously relieved.Conclusion:Danhong injection can decrease renal ischemia reperfusion injury after renal transplantation

possiblely by down-regulating ICAM-1 expression.