Objective:To investigate the expression of Smad4 and Smad7 in different gastriccarcinoma tissues

and to explore the ireffect on gastric cancer.Methods:The expression of Smad4 and Smad7 was examined by using immunohistochemistry(SP method)in different gastric tissues

including 78 cases of pathologically confirmed gastric carcinomas and 78 cases of adjacent non-cancerous mucosa.Results:①The positive rate of Smad4 expression was 69.23% in lateral spherical aberration tissues of gastric cancer

and 44.87% in gastric cancer tissues(P<0.01).The positive rate of Smad4 expression was descended as the differentiated degree of gastric cancer was descended.There was also a significant difference in the Smad4 expression between lymph node metastasis positive and lymph node metastasis negative tumors(23.25% Vs 71.43%

P<0.01).②The positive rate ofSmad7 expression was 17.95% in lateral spherical aberration of gastric cancer tissues

and 89.74% in gastric cancer tissue(sP<0.01).The positive rate ofSmad7 expression was increased as the differentiated degree of gastric cancer was descended.There was also a significant difference in the Smad7 expression between lymph node metastasis positive and lymph node metastasis negative tumors(97.67% vs 80.0%

P<0.05).Conclusions:①The expression of Smad4 was low in gastric cancer tissue

Which was significantly difference that in the lateral spherical aberration of gastric cancer tissues(P<0.01).The positive rate of Smad4 expression was related to the differentiated degree and metastasis of gastric cancer.②The expression of Smad7 was high in gastric cancer tissue

which was significantlydifference that in the lateral spherical aberration ofgastric cancer tissues(P<0.01).The positive rate of Smad4 expression was related to differentiated degree and metastasis.