解热镇痛类药物对神经病理性疼痛患者疼痛及转移生长因子TGF-β<sub>1</sub>的影响

孙琳; 冷冬梅; 文传兵; 刘慧; 左云霞

doi:10.13406/j.cnki.cyxb.2010.01.033

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解热镇痛类药物对神经病理性疼痛患者疼痛及转移生长因子TGF-β₁的影响

临床研究 | 更新时间：2024-01-17

- 解热镇痛类药物对神经病理性疼痛患者疼痛及转移生长因子TGF-β₁的影响
- Effects of antipyretic analgesic drugs on pain and transforming growth factor TGF-β₁ of patients with neuropathic pain
- 重庆医科大学学报 2010年35卷第1期页码：68-71
- 作者机构：
  
  四川大学华西医院麻醉科
- 作者简介：
- 基金信息：
  
  国家自然科学基金神经病理性疼痛发病机制研究（编号:30571786）
- DOI：10.13406/j.cnki.cyxb.2010.01.033
  中图分类号： R741.02
- 纸质出版日期：2010，
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[1]孙琳,冷冬梅,文传兵,刘慧,左云霞.解热镇痛类药物对神经病理性疼痛患者疼痛及转移生长因子TGF-β_1的影响[J].重庆医科大学学报,2010,35(01):68-71.

SUN Lin, et al. Effects of antipyretic analgesic drugs on pain and transforming growth factor TGF-β₁ of patients with neuropathic pain[J]. Journal of Chongqing Medical University, 2010,35(1):68-71.
[1]孙琳,冷冬梅,文传兵,刘慧,左云霞.解热镇痛类药物对神经病理性疼痛患者疼痛及转移生长因子TGF-β_1的影响[J].重庆医科大学学报,2010,35(01):68-71. DOI： 10.13406/j.cnki.cyxb.2010.01.033.

SUN Lin, et al. Effects of antipyretic analgesic drugs on pain and transforming growth factor TGF-β₁ of patients with neuropathic pain[J]. Journal of Chongqing Medical University, 2010,35(1):68-71. DOI： 10.13406/j.cnki.cyxb.2010.01.033.

摘要

目的:通过研究使用解热镇痛药（Non-steroid alantiinflammatory drugs

NSAIDs）类药物治疗的神经病理性疼痛患者与未使用NSAIDs类药物治疗的神经病理性疼痛患者疼痛情况与TGF-β（1Transforming growth factor

TGF-β1）变化情况

分析使用NSAIDs类药物对疼痛的影响及对TGF-β1的影响

探讨TGF-β1在神经病理性疼痛中的作用。方法:选择我院2006～2007年符合神经病理性疼痛纳入标准的疼痛门诊及住院患者

收集神经病理性疼痛患者的资料

采用100mm视觉模拟评分法对患者进行疼痛程度的评估

抽取静脉血进行细胞因子TGF-β1检测。结果:使用和未使用NSAIDs类药物治疗的神经病理性疼痛患者的年龄、性别和病程上并无显著差异（P>0.05）。使用和未使用NSAIDs类药物治疗的神经病理性疼痛患者的疼痛评分和TGF-β1上并无显著差异（P>0.05）。PHN（Postherpetic neuralgia

PHN）患者、三叉和舌咽神经痛患者、颈椎病和腰椎间盘突出症患者的疼痛评分和TGF-β1组间比较上

使用NSAIDs类药物的PHN患者、三叉和舌咽神经痛患者的TGF-β1较颈椎病和腰椎间盘突出症患者有显著降低（P<0.05）;未使用NSAIDs类药物的PHN患者、三叉和舌咽神经痛患者的TGF-β1较颈椎病和腰椎间盘突出症患者有显著降低（P<0.05）。结论:使用和未使用NSAIDs类药物对神经病理性疼痛患者的疼痛和TGF-β1没有显著影响;颈椎病和腰椎间盘突出症发生机制可能与TGF-β1相关。

Abstract

Objective:To observe the effects of antipyretic an algesic drugs(NSAIDs)on pain and transforming growth factor TGF-β1of patients with neuropathic pain by comparing with patients who were not administered NSAIDs to discuss the function of TGF-β1 in neuropathic pain.Methods:Patients clinically diagnosed at least by two pain physicians as neuropathic pain for more than 3 months

with the written consent to participate the clinical survey and to donate the blood for immune function test either in pain outpatient or pain ward in West China Hospital

from the year 2006 to 2007 were recruited.100mm visual analogue score was used to assess the extent of pain.Venous blood samples were detected for cytokine lectin TGF-β1.Results:There were no significant difference of age

sex or disease course between the two groups(P>0.05).There was no significant difference of pain score and TGF-β1 between patients with neuropathic pain administered NSAIDs drugs and those administered no NSAIDs drugs(P >0.05).TGF-β1 of patients with PHN

trigeminal and glossopharyngeal neuralgia either administered NSAIDs drugs or not were significantly lower than patients with Cervical spondylosis and lumbar disc herniation either administered NSAIDs drugs or not respectively(P<0.05).Conclusions:There are no significant effects of NSAIDs on pain and TGF-β1of patients with neuropathic pain.The pathogenesis of cervical spondylosis and lumbar disc herniation may associated with TGF-β1.

关键词

解热镇痛药神经病理性疼痛疼痛生长因子

Keywords

Antipyretic analgesicsNeuropathic painpaingrowth factor

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解热镇痛类药物对神经病理性疼痛患者疼痛及转移生长因子TGF-β1的影响

Effects of antipyretic analgesic drugs on pain and transforming growth factor TGF-β1 of patients with neuropathic pain

DOI：10.13406/j.cnki.cyxb.2010.01.033

摘要

Abstract

关键词

Keywords

references

解热镇痛类药物对神经病理性疼痛患者疼痛及转移生长因子TGF-β₁的影响

Effects of antipyretic analgesic drugs on pain and transforming growth factor TGF-β₁ of patients with neuropathic pain