载脂蛋白E基因型多态性与SAH后血管痉挛的相关研究

阮健; 谢延风; 孙晓川; 苏海; 江涌; 唐文渊

doi:10.13406/j.cnki.cyxb.2010.01.032

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载脂蛋白E基因型多态性与SAH后血管痉挛的相关研究

临床研究 | 更新时间：2024-01-17

- 载脂蛋白E基因型多态性与SAH后血管痉挛的相关研究
- Association of Apolipoprotein E genotypes polymorphisms with cerebral vasospasm after spontaneous subarachnoid hemorrhage
- 重庆医科大学学报 2010年35卷第1期页码：79-83
- 作者机构：
  
  1. 重庆医科大学附属第一医院神经外科
  2. 重庆市第二人民医院神经外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.01.032
  中图分类号： R743.35
- 纸质出版日期：2010，
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[1]阮健,谢延风,孙晓川,苏海,江涌,唐文渊.载脂蛋白E基因型多态性与SAH后血管痉挛的相关研究[J].重庆医科大学学报,2010,35(01):79-83.

RUAN Jian, et al. Association of Apolipoprotein E genotypes polymorphisms with cerebral vasospasm after spontaneous subarachnoid hemorrhage[J]. Journal of Chongqing Medical University, 2010,35(1):79-83.
[1]阮健,谢延风,孙晓川,苏海,江涌,唐文渊.载脂蛋白E基因型多态性与SAH后血管痉挛的相关研究[J].重庆医科大学学报,2010,35(01):79-83. DOI： 10.13406/j.cnki.cyxb.2010.01.032.

RUAN Jian, et al. Association of Apolipoprotein E genotypes polymorphisms with cerebral vasospasm after spontaneous subarachnoid hemorrhage[J]. Journal of Chongqing Medical University, 2010,35(1):79-83. DOI： 10.13406/j.cnki.cyxb.2010.01.032.

摘要

目的:探讨载脂蛋白E基因（ApolipoproteinE

APOE）多态性与自发性蛛网膜下腔出血（Subarachnoid hemorrhage

SAH）后脑血管痉挛（Cerebral vasospasm

CVS）的相关性。方法:采用聚合酶链反应限制性片段长度多态性（Polymerase chain reaction-restriction fragment length polymorphism

PCR-RFLP）检测185例SAH患者

测定APOE基因型多态性

通过TCD评定SAH患者出血后的CVS情况。分型结果与CVS及相关临床资料等分别进行χ2检验和Logistic回归分析。结果:185例SAH患者中

32例APOEε4携带者中有21例（占65.7%）发生CVS

153例非ε4携带者中有56例（占36.7%）发生CVS

ε4携带者的CVS发生率明显高于非ε4携带者（P=0.022）;单因素和多因素Logistic回归均提示ε4是CVS的危险因素。结论:APOEε4等位基因是SAH患者发生CVS的危险因素。

Abstract

Objective:To investigate the influence of the apolipoprotein E(APOE)gene polymorphisms on cerebralvasospasm(CVS) in patients with spontaneous subarachnoid hemorrhage(SAH).Methods:One hundred and eighty-five patients with spontaneous SAH were selected in this study.Venous blood samples and clinical data of the patients were collected.The APOE polymorphisms of all patients were determined by PCR-RFLP.Associations of APOE genotypes polymorphisms with cerebral vasospasm after SAH were analyzed by χ2 test

Uni-and multivariate logistic regression.Results:In 185 patients

21 of 32(65.7%)patients with APOEε4 allels showed CVS

whileonly 56(36.7%)out of 153 patients without APOEε4 showed it.Incidence rate of CVS in ApoEε4(+)group was significantly higherthanthatinAPOEε4(-)(P=0.022).Uni-andmultivariate logistic regression analyses demonstrated that APOEε4 allel was a risk factor for CVS.Conclusions:Our findings suggest that the patients with APOEε4 alleles are predisposed to have CVS after spontaneous SAH.

关键词

载脂蛋白E基因多态性蛛网膜下腔出血脑血管痉挛

Keywords

apolipoprotein EGenotype polymorphismsubarachnoid hemorrhagecerebral vasospasm

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