Objective:To evaluate the comparative efficacy of Immunoadsorption(IA) versus Low dose alternate day plasma exchange(PE) in patients with acute inflammatory demyelinating polyneuropathy(AIDP).Methods:36 patients with AIDP were studied retrospectively.15 were treated with IA

and 21

with Lowdose alternate day PE.The neurological deficits of both groups were evaluated by Hughes scale and Medical Research Council(MRC)-score

based on which the improvement of neurological deficits and clinical efficacy were observed.Results:Both therapies improved the neurological deficits of the patients with AIDP

and there was no significant difference between them.The whole effective rate was much higher in the IA group on the 1st day after the treatment

but no significant difference was found at 1 week and 2 weeks between the two groups

which showed no significant difference in effective rate between the two groups according to the clinical types and the age stratification study.Conclusion:Compared with low dose alternate day PE

IA therapy was found with approximately the same efficacy.Therefore

IA is recommended as an alternative plasmapheresis method.