YU Qiu-bo, et al. Expression profile analysis of human spontaneous abortion extravillous trophoblast cells[J]. Journal of Chongqing Medical University, 2010,35(1):18-22.
YU Qiu-bo, et al. Expression profile analysis of human spontaneous abortion extravillous trophoblast cells[J]. Journal of Chongqing Medical University, 2010,35(1):18-22. DOI: 10.13406/j.cnki.cyxb.2010.01.024.
Objective:To investigate the expression changes ofinvasion-relevant genes in spontaneous abortion Extravillous trophoblast cells(EVTs).Methods:The U133 plus2.0 gene chips were used to analyze gene expression profiles in spontaneous EVTs and normal EVTs.The results were analyzed by bioinformatics methods.Results:Compared with normal EVTs
219 and 293 genes in spontaneous abortion EVTs were up-regulated and down-regulated respectively.These genes were mainly associated with signal transduction
apoptosis
metabolism
immune response
etc.Conclusion:Differential expression of genes related with apoptosis
immune response
hydratase
cell adhesion may play a role in the EVTs’abnormal invasion and spontaneous abortion.