Objective:To investigate the effect of low calcium dialysate on calcium and phosphorus metabolism and arterialcompliance in continuous ambulatory peritoneal dialysis(CAPD)patients with high or normal serum calcium

and provide a optimal treatment for those patients.Methods:Thirty-one CAPD patients(standard cacium dialysate

calcium carbonate intake(2.56±0.51)g/d with high or normal serum calcium(corrective serum calcium >2.12 mmol/L、iPTH<150 pg/ml)were selected in this study.Standard calcium dialysate solution(1.75 mmol/L)was changed to lower calcium dialysate(Baxter PD4 with calcium concentration 1.25 mmol/L).Calcium carbonate(3 g/d) was used at the meantime.The serum levels of calcium

phosphorus

albumin

alkaline phosphatease

natrium

creatinine(Scr)

blood urea nitrogen(BUN)

hemachrome

TC

TG

LDL

C-Reactive protein(CRP)

intact parathyroid hormone(iPTH)were detected periodically at 0

4 th

8 th

12 th week.The arterial compliance were echocardiographically examined at the same time.baPWV and ABI were measured by the VP-1000 automatic ateriosclerosis measurement system.Results:After changing to PD4

serum calcium

phosphorus concentration and calcium phosphorus product decreased

serum iPTH increased significantly but maintained an acceptable level afterwards.The changes in ACI and baPWV were statistically significant after 8th week.The changes in serum calcium(8 th

12 th week)was a variable correlating with the simultaneous changes of ACI(r=-0.44

r=-0.38;P<0.05)and baPWV(r=0.48

r=0.43;P<0.05).The changes in serum calcium phosphorus product(12th week)and serum phosphorus(12 th week) were also variables correlating with the simultaneous changes ofACI(r=-0.47

P<0.05;r=-0.52

P<0.05).Conclusion:There were favorable changes in serum calcium

phosphorus and calcium phosphorus product in CAPD patients with high or normal serum cacium after treatment with low calcium dialysate and adequate calcium carbonate intake.As a result

the arterial compliance were improved in those patients.