Objective:To investigate the expression of GIPR in vasculature endothelial cells in transplanted islets.Methods:Pancreas of SD rat were digested by collagenase V after the common bile ductal injection of collagenase V.Islets were purified by Ficoll discontinuous density gradient-centrifugation.Then the high-quality islets were immediately transplanted intraportally into the liver of recipient SD rats with streptozotocin-induced diabetes.The recipient rats were randomly devided into 4 groups based on time points that recipients were killed:group A(7 days)、group B(14 days)、group C(40 days)

and group D(60 days).The immunosuppressive tacrolimus(FK506)and mycophenolate mofeti(lMMF)were administered to recipients by intragastric administration aftertransplantation.Concentrations of blood glucose in recipient were determined with monitor .The groups were respectively killed at different time points

then islet grafts and the expression of GIPR in vasculature endothelial cells were observed morphologically.Results:GIPR was found to be expressed in parts of the microvascular endothelial cells

Conclusion:GIPR-positive endothelial cells take part in microvascular reconstruction in islet grafts.The neogenetic islet endothelial cells might acquire some common characteristics with those of liver.