Objective:To evaluate the expressions of HIF-1αand VEGF in gastric cancers

and explore the correlation between HIF-1αand VEGF.Methods:The expressions of HIF-1αand VEGF in 84 specimens of gastric cancer and paracancerous normal tissues were detected by SP immunohistochemistry and the correlations of HIF-1αand VEGF to clinicopathologic features and association between HIF-1αand VEGF were analyzed with Sas 8.0 software.Results:Of the 84 specimens

the positive rate of HIF-1αexpression was 60.7%(51/84)

and it was much higher than that in paracancerous normal tissues (16.7%

14/84

P<0.05).HIF-1αexpression in tissues with lymph node metastasis(79.1%) was much higher than that in tissues without no lymph node metastasis 41.5%(P<0.05).The expression rates of HIF-1αin cancer tissues with the invasion depth as the mucous membrane or under

muscle layer or under serosa

and penetrating the serosa were 29.2%

62.2% and 91.3% respectively(P<0.05).Expression rates of HIF-1αin cancer tissues with no or low differentiation

and medium or high differentiation were 76% and 54.2% respectively(P>0.05).Expression rates in cancer tissues with tumor size≤5cm and>5cm were 64.7% and 58% respectively(P<0.05)

The rate for male was 63% while that for female was 59.7%(P>0.05)

The rate for patients aged<60 was 52.3%

while that for those aged≥60 was 70%(P>0.05)。The positive rate of VEGF expression was 73.8%(62/84).The expression of VEGF was significantly associated with that of HIF-1α(P<0.05).Conclusion:The expression of HIF-1αis correlated to lymph node metastasis and the depth of invasion

The function of HIF-1αrealizes partially through the expression of VEGF.Therefore

HIF-1αcould serve as a parameter for evaluating malignancy and prediction of prognosis of gastric cancer and HIF-1αmay be a direction of clinical therapy.