Objective:To evaluate the establishment method and bionomics of VX2 lung cancer models in rabbits.Methods: VX2 tumor fragments

preserved from autoinculation rabbits into the lungs of healthy rabbits to establish the models

and then the tumorous growth was observed through the imageology and the morphology of the samples including the lung

the cardia

the liver

the kidney

the brain and lymphatic gland after death at different time.Results:(1) the achievement ratio of modeling was 100%。(2)The VX2 tumor discovered evidently in lung were displayed for diffuse

inequality of size

tuberculum and fish surface.It was visible that metastatic tumor

which were invasion

were discovered evidently in all six organs except for the brain after vaccination for six days.(3)Squamous cell carcinoma

which was originated from epithelial tissue

was confirmed through pathologic histology and immunohistochemistey.Conclusions:The construction of VX2 tumor animal models in rabbits by applying organism fragments not only is simple in method

free from infection and high in achievement ratio but also the biological behaviour of VX2 is similar to human tumors

with high level of malignancy.This study provides valuable guidance for the construction of the large animal models of the lung cancer.