Objective:To investigate plasma resistin lever in maintenance hemodialysis(MHD)patients and explore its relationship with micruinflammation. Methods:73 patients with MHD and 20 heahhy volunteers were involved in this study. Plasma concentrations of IL-6

TNF-α

resistin were measured by enzyme linked immunoassay(ELISA). The serum levels of high sensitivity C-reactive protein (CRP)

triglyceride

cholesterol

albumin

glucose and insulin were also detected. The homeostasis model assessment index(HOMA-R) was calculated as an estimate of insulin resistance from the fasting glucose and insulin. Results:The plasma lever of resistin in MHD was significantly increased compared with healthy controls(40.15±22.46 vs 11.78±6.29 ug/L

P<0.01). The levels of CRP

IL-6

TNF-αwere also significantly higher in MHD as compared with heahhy control(4.56±1.46 vs 2.10±0.67 mg/L

P<0.01; 90.19±32.04 vs 49.30±28.12 ng/l

P<0.01; 115.16±90.35 vs 48.21±36.54 ng/L

P<0.01;respectively). A significant positive correlation was observed between the serum resistin and CRP (r=0.246

P<0.05). However plasma resistin levels were not correlated with the levels of IR. Conclusions:The level of resistin in MHD is significant higher compared with heahhv controls and correlated with microinflammation. Resistin is probahly playing important effect on the cardiovascular injury of end stage renal disease.