Objective:To investigate the clinical significance of the expression of Survivin and p53 in cervical carcinoma.Meth- ods:Expression of Survivin and p53 in sixty paraffin-embedded specimens of cervical carcinoma patients were examined by us- ing the immunohistochemistry method.Results:The positive expressions rates of Survivin and p53 in sixty cervical carcinoma specimens were 90%

53.33% respectively.The positive expressions of Survivin were not associated with age

differentiation grade

neoadjuvant chemotherapy and lymph node metastasis

but were highly associated with clinical stage.The positive expres- sions of p53 were not associated with age and differentiation grade

but highly associated with clinical stage

neoadjuvant chemotherapy and lymph node metastasis.The positive rate of the co-expression of Survivin and p53 in sixty specimens was 51.67%

and it was especially higher in the patients who experienced neoadjuvant chemotherapy(85%)or had lymph node metastasis(91.67%).Conclusions:The expressions of Survivin and p53 in cervical carcinoma might cooperatively play an im- portant role in the progression and deterioration of cervical carcinoma.