Objective:To identify the presence of clinical evolution

electroencephalographic and neuroimaging patterns of Ras- mussen’s syndrome（RS）.Methods:By means of EEG

CT

MRI and observation of clinical evolution and drug therapy as well as reviewing the referential data.Results:The two children with Rasmussen’s syndrome were the age of onset between 26 months and 6 year 8 months

characterized by repetitive focal epileptic seizures or chronic progressive epilepsia partialis continua and secondarily generalized convulsive seizures dominant from one side followed by slowly progressive neurological deterioration in- cluding hemiparesis

cognitive impairment and dysphasia

where the dominant hemisphere is involved.Focal delta and theta or delta intermingled slowly with small spikes or sharp waves were steadily recorded in EEG;Radiological evidence of increased signal intensity on T

2

-weighted images and progressive

usually unilateral

cerebral atrophy are highly suggestive of RS;Conven- tional antiepileptic drug therapies are poorly responsive.Conclusion:Rasmussen’s syndrome is an unusual pattern of focal epileptic syndrome characterized by unique clinical evolution

electroencephalographic and neuroimaging changes

in which the pathophysiology and optimum treatment are worthy of being explored.