Objective:To investigate the effect of intravenous immunoglobulin(IVIG)on the panel reactive antibody(PRA)in renal transplantation.Methods:57 highly sensitized patients awaiting renal transplantation

age 21 to 65 years

the value of PRA were 35% to 91%(mean46.7%±29.5%).All received the treatment by IVIG 5g/d

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period of treatment was 2 weeks.We ex- amined the value of PRA before treatment and after treatment of IVIG.Results:36 patients used one period of treatment

15 patients used two period of treatment

6 patients used three period of treatment.After treatment of IVIG

the value of PRA de- creased to non-sensitivity in 48 patients

completely no decreased in 3 patients

partly decreased in 6 patients.The patients re- sulted in reduction in PRA of 0～61%(mean decrease:38.4%±16.3%)

there were significant difference in patients with treat- ment of IVIG.All patients received renal transplantation which CDC less than 10%

there were no hyperacute rejection ap- pearance.After operation

there were 2 patients(3.5%)occurred acute rejection and treated with MP plus FK506

the renal function returned normal gradually.Conclusion:Intravenous injection of high dose of IVIG could reduce the value of PRA in some highly sensitized patients and could increased the rate of succeed in renal transplantation.