Objective:To discuss the clinical use of endoscopic Sphincterotomy(EST)and endoscopic nosalbiliary drainage(ENBD) in the treatment of severe acute pancreatitis.Methods:77 patients were divided into the endoscopic treatment group and contol group.EST plus ENBD were performed in patients of the endoscopic treatment group 24h after hospitalization.The control group were treated with the combination of treatment.Blood was drawn in each group the day and 48h following hospitalization for amylase measurement.The time of bellyache relief.the morbidity rate and hospital stay were also observed.Results:48h after hospitalization amylase measurement was significiantly lower in endoscopic treatment group 982μmol/L±24μmol/L than that in control group(1576μmol/L±31μmol/L

P<0.05).The bellyache relief rate was significiantly lower in control group(P<0. 05);the morbidity rate and hospital stay were much significiantly lower in EST group than those in the control group(P<0.01). Conclusion:The excellence of EST and ENBI)in the treatment group of severe acute pancreatitis is significiantly higher than that in control groups

It is recommended to perform EST and ENBD for severe acute pancreatitis of the onset of the discase which should be within72 hours.