Objective To investigate the effects of propofol combined with fentanyl or remifentannil during painless gastroscopy . Methods Sixty patients were randomly divided into two groups

group A (remifentannil

n =30) and group B (fenlanyl

n =30). All patients were induced with intravenous propofol (1.5-2. 0 mg/kg )

then maintained with propofol to provide anesthesia during examination according to the reaction of patient. Intravenous remifentannil (0. 5μg/kg) were used in group A

and Intravenous fentanyl (0. 05mg) were used in group B. Blood oxygen saturation

heart rate

blood pressure

dosages of propofol

examination time

revival time and walkable time were recorded and analyzed. Results Revival time and walkable time in group A were significantly shorter than those in group B. Dosages of propofol in group B were little higher than those in group A. Conclusion The application of propofol combined with remifentannil during painless gastroscopy may be safer and more satisfied anesthesia compared with propofol combined with fentanyl.