Objective:To comprehend the clinical significance of anticentromere antibodies(ACA)positive in patients.Methods:A total of 26 patients with positive ACA were studied retrospectively.Results:There were 10 patients with systemic sclerosis(38.4%)

4 patients with systemic lupus erythematosus(15.4%)

3 patients with Sjogren’s syndrome and rheumatoid arthritis(11.5%)respectively

2 patients with mixed connective tissue disease and Raynaud phenomenon(7.7%)respectively

1 patient with CREST syndrome and 1 patient with liver disease of unknown causes (3.8%).ACA and other autoantibodies were present in serum at the same time.Conclusion:ACA is found in many diseases.ACA is not specific for CREST syndrome.The major clinical characteristics of the patients correlated with ACA are Raynaud phenomenon(53.8%)and scleroderma(34.6%).