Beta-Cetnin和APC蛋白在卵巢上皮肿瘤中的表达及意义

林晓; 李昱; 张雄

doi:10.13406/j.cnki.cyxb.2005.03.026

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Beta-Cetnin和APC蛋白在卵巢上皮肿瘤中的表达及意义

更新时间：2024-01-17

- Beta-Cetnin和APC蛋白在卵巢上皮肿瘤中的表达及意义
- Expression of beta-catenin protein APC in ovarian epithelial tumor and its implication
- 重庆医科大学学报 2005年第3期页码：402-404
- 作者机构：
  
  1. 重庆医科大学病理教研室
  2. 重庆医科大学病理教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.03.026
  中图分类号： R737.31
- 纸质出版日期：2005，
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[1]林晓,李昱,张雄.Beta-Cetnin和APC蛋白在卵巢上皮肿瘤中的表达及意义[J].重庆医科大学学报,2005(03):402-404+408.

LIN Xiao, et al. Expression of beta-catenin protein APC in ovarian epithelial tumor and its implication[J]. Journal of Chongqing Medical University, 2005,(3):402-404.
[1]林晓,李昱,张雄.Beta-Cetnin和APC蛋白在卵巢上皮肿瘤中的表达及意义[J].重庆医科大学学报,2005(03):402-404+408. DOI： 10.13406/j.cnki.cyxb.2005.03.026.

LIN Xiao, et al. Expression of beta-catenin protein APC in ovarian epithelial tumor and its implication[J]. Journal of Chongqing Medical University, 2005,(3):402-404. DOI： 10.13406/j.cnki.cyxb.2005.03.026.

摘要

目的:探讨卵巢良性上皮肿瘤

卵巢交界性上皮肿瘤及卵巢恶性上皮肿瘤中beta-Catenin和APC蛋白的表达及意义。方法:采用ABC免疫组织化学染色方法检测18例卵巢良性上皮肿瘤

13例卵巢交界性上皮肿瘤及17例卵巢恶性上皮肿瘤中beta-Catenin和肿瘤APC蛋白的表达。结果:卵巢恶性上皮肿瘤beta-Catenin异常表达率明显高于卵巢良性上皮肿瘤（P<0.001）

卵巢交界性上皮肿瘤beta-Catenin异常表达率亦明显高于卵巢良性上皮肿瘤（P<0.01）;APC蛋白在卵巢良性上皮肿瘤的表达明显强于卵巢恶性上皮肿瘤

两者具有显著性差异（P<0.05）;卵巢上皮肿瘤中beta-Catenin和APC蛋白之间存在负相关

且具有统计学意义（r=-0.352

P<0.05）。结论:beta-Catenin

APC蛋白在卵巢上皮肿瘤的发生

发展过程中起重要作用。

Abstract

Objective:To investigate the expression of beta-catenin

protein APC and its implication in ovarian epithelial tumor.Methods:Immunohistochemical staining with ABC method was conducted to determine the expression of beta-catenin and protein APC in 48 cases of ovarian epithelial tumors.Results:The rate of beta-catenin in ovarian malignant epithelial tumor was higher than that in benign epithelial tumor

and the rate in borderline epithelial tumor was higher than that in benign epithelial tumor too.There was significant difference between them.The prevalence of protein APC positive in ovarian benign epithelial tumor was significantly greater than that in ovarian malignant epithelial tumor.A significant negative correlation was found between beta-catenin and protein APC in ovarian epithelial tumor.Conclusion:The results suggest that beta-catenin and APC protein have important effects on pathogenesis and development of ovarian epithelial tumors.

关键词

卵巢上皮肿瘤beta-CateninAPC蛋白免疫组织化学染色

Keywords

Ovarian epithelial tumorBeta-cateninAPC proteinImmunohistochemistry

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Beta-Catenin,APC蛋白,C-myc及CyclinD₁在卵巢上皮肿瘤中的表达及意义