Objective:To compare the effects of simvastatin

xuezhikang and pravastatin in patients with primary hyperlipidemia.Methods:Sixty patients were randomly divided into three groups

simvastatin 20mg were taken once a day at night;provastatin 10mg were taken once a day at night;xuezhikang 0.6g were taken twice a day in the morning and at night.Blood samples were taken before and 4 weeks

8 weeks

12 weeks after the treatment.Results:In simvastatin group:the serum levels of total cholesterol(TC)

low-density lipoprotein cholesterol(LDL C) decreased markedly at the end of 4 weeks compared with those of the baseline ( P <0.05).Significant differences in TC

LDL C were found between the end of 4 weeks and 12 weeks ( P <0.05).In pravastatin group:there is a noticeable drop in TC

LDL C at the end of 4 weeks

but no further obvious drop between 4 weeks and 12 weeks.Concentrations of TG and HDL C were not changed obviously in both groups after 12 weeks of treatment compared with the baseline ( P >0.05).In xuezhikang group:after 4 weeks of treatment

TC

TG

LDL C reduced markedly( P <0.05).Further significant lowering of TC

LDL C were noted after 12 weeks as compared with 4 weeks ( P <0.05).Only HDL C was not changed after the treatment in contrast with the baseline ( P >0.05).From the change rates

we can see after 8 weeks

12 weeks of treatment the level of LDL C drcreased more significantly in simvastatin group (40%

45%) than in xuezhikang (31%

36%) and provastatin (31%

35%) ( P <0.05);however

the level of TG lowered more obviously in xuezhikang group (33%

35%) than in simvastatin(25%

26%) and provastatin (18%

19%)( P <0.05).At the end of 12 weeks

the total effective rates of decreasing TC

TG

HDL C have no significance among three groups ( P >0.05).Conclusion:The clinical effects of simvastatin

xunzhikang

provastatin on primary hyperlipidemia were equal among the three groups

but the time is different about when they take great effects respectively.Next

LDL C lowering effect of simvastatin was significant.Finally

xuezhikang was the best in reducing TG among the three groups and it has a relatively good economic effectiveness.