HUA Yi, et al. Correlation study on matrix metalloproteinase-3 and tumors in children[J]. Journal of Chongqing Medical University, 2005,(2):263-265. DOI: 10.13406/j.cnki.cyxb.2005.02.028.
Objective:To study the relationship between MMPs and the metastasis and the malignant degree of tumors in children.Methods:The expression of MMPs in different tumor groups was measured by means of immuno-histochemistry.Results:The expressions of MMP-3 in cytoplasm of tumor cells were observed.There was significant difference( P <0.05) among the groups.Conclusion:In solid tumors of children
the expression of MMP-3 has close relationship with degree of malignancy.The stronger the expression of MMP-3 is
the higher the degree of malignancy is and the more probable the metastasis.It suggests that MMP-3 could be a marker to forecast the metastasis of tumors and to estimate the prognosis of tumors.