高强度聚焦超声损伤兔肝脏的剂量及二维超声实时监控

肖子文; 肖雁冰; 刘丽萍; 李发琪; 王智彪

doi:10.13406/j.cnki.cyxb.2005.01.012

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高强度聚焦超声损伤兔肝脏的剂量及二维超声实时监控

更新时间：2024-01-17

- 高强度聚焦超声损伤兔肝脏的剂量及二维超声实时监控
- Dosage and real time monitoring using two-dimensional ultrasound in extracorporeal damaging rabbit liver with high intensity focused ultrasound
- 重庆医科大学学报 2005年第1期页码：42-45
- 作者机构：
  
  1. 重庆医科大学生物医学工程系
  2. 重庆医科大学超声工程研究所,重庆,400016
- 作者简介：
- 基金信息：
  
  国家杰出青年基金资助（30325027）,本单位为省部共建国家重点实验室。
- DOI：10.13406/j.cnki.cyxb.2005.01.012
  中图分类号： R312
- 纸质出版日期：2005，
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[1]肖子文,肖雁冰,刘丽萍,李发琪,王智彪.高强度聚焦超声损伤兔肝脏的剂量及二维超声实时监控[J].重庆医科大学学报,2005(01):42-45.

XIAO Ziwen, et al. Dosage and real time monitoring using two-dimensional ultrasound in extracorporeal damaging rabbit liver with high intensity focused ultrasound[J]. Journal of Chongqing Medical University, 2005,(1):42-45.
[1]肖子文,肖雁冰,刘丽萍,李发琪,王智彪.高强度聚焦超声损伤兔肝脏的剂量及二维超声实时监控[J].重庆医科大学学报,2005(01):42-45. DOI： 10.13406/j.cnki.cyxb.2005.01.012.

XIAO Ziwen, et al. Dosage and real time monitoring using two-dimensional ultrasound in extracorporeal damaging rabbit liver with high intensity focused ultrasound[J]. Journal of Chongqing Medical University, 2005,(1):42-45. DOI： 10.13406/j.cnki.cyxb.2005.01.012.

摘要

目的探索高强度聚焦超声损伤兔肝脏的剂量和二维超声实时监控的可行性。方法HIFU发射功率、工作频率、辐照深度恒定

以HIFU定点损伤40例兔肝脏

二维超声实时观察损伤靶区的回声及其随时间的变化

测量回声变化的范围

解剖测量损伤靶区凝固性坏死区的大小

留取凝固性坏死组织标本行病理学检查。结果HIFU体外辐照兔肝脏可在靶区形成凝固性坏死

能效因子为9.22±1.57J/mm3

靶区的回声增强

凝固性坏死体积、最大剖面面积与二维超声测量的回声增强区体积、面积呈线性关系。结论HIFU损伤组织的剂量需大量的实验研究

二维超声可实时监控凝固性坏死的出现

并可预测凝固性坏死体积大小。

Abstract

Objective:To investigate the dosage in damaging rabbit liver with high intensity focused ultrasound (HIFU) and the feasibility of real time monitoring with two-dimensional ultrasound.Methods:With fixed HIFU emission power

working frequency

radiation depth

40 rabbit livers were damaged extracorporeally with a HIFU mode of intermittent fixed-spot irradiation.Echo of target region was measured and its changes with time were observed

the extent of echo enhancing region were also measured.Coagulative necrosis in rabbit livers were measured after dissection and pathological inspection were made.Results:Irradiation of extracorporeal HIFU made a coagulative necrosis region in rabbit liver

energy efficiency factor (EEF) were 9.22±1.57 J/mm 3

elevating echo of target region were observed

necrotic volume and maximum scar of rabbit livers were related linearly with volume and maximum area of elevating echo region measured by two-dimensional ultrasound.Conclusion:For specific tissue

there are a great deal experiments to do to decide a common HIFU dosage

two-dimensional ultrasound can realize real time monitoring of target region necrosis

echoic change in target region can predict coagulative necrotic volume.

关键词

高强度聚焦超声剂量能效因子监控

Keywords

high intensity focused ultrasoundDosageEnergy efficiency factorMonitoring

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