四项肿瘤标志物测定对癌性、结核性胸腔积液的鉴别诊断价值

梅同华; 徐小杰

doi:10.13406/j.cnki.cyxb.2004.06.034

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四项肿瘤标志物测定对癌性、结核性胸腔积液的鉴别诊断价值

更新时间：2024-01-17

- 四项肿瘤标志物测定对癌性、结核性胸腔积液的鉴别诊断价值
- The diagnostic value of measurement of 4 tumor markersin the patients with cancer and tuberculous pleural effusion
- 重庆医科大学学报 2004年第6期页码：814-816
- 作者机构：
  
  1. 重庆医科大学第二临床学院呼吸内科
  2. 重庆医科大学第二临床学院呼吸内科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.06.034
  中图分类号： R817.4
- 纸质出版日期：2004，
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[1]梅同华,徐小杰.四项肿瘤标志物测定对癌性、结核性胸腔积液的鉴别诊断价值[J].重庆医科大学学报,2004(06):814-816.

MEI Tonghua, et al. The diagnostic value of measurement of 4 tumor markersin the patients with cancer and tuberculous pleural effusion[J]. Journal of Chongqing Medical University, 2004,(6):814-816.
[1]梅同华,徐小杰.四项肿瘤标志物测定对癌性、结核性胸腔积液的鉴别诊断价值[J].重庆医科大学学报,2004(06):814-816. DOI： 10.13406/j.cnki.cyxb.2004.06.034.

MEI Tonghua, et al. The diagnostic value of measurement of 4 tumor markersin the patients with cancer and tuberculous pleural effusion[J]. Journal of Chongqing Medical University, 2004,(6):814-816. DOI： 10.13406/j.cnki.cyxb.2004.06.034.

摘要

目的 :探讨癌胚抗原（CEA）、糖类抗原（CA199、CA12 5、CA15 3）对癌性和结核性胸腔积液的鉴别诊断价值。方法 :应用放射免疫法对 6 4例癌性胸腔积液、4 4例结核性胸腔积液及 2 0例健康人的血清、胸水进行观察。结果 :癌性胸腔积液患者血清和胸水CEA、CA199、CA12 5、CA15 3水平分别为 32 .4± 9.1、4 4 .5± 16 .4、39.6± 14 .2、34.7± 12 .3和 5 2 .6± 12 .1、6 2 .0±17.2、5 7.4± 13.2、5 6 .3± 10 .1

均显著高于健康对照组和结核性胸液组

且胸水 /血清比值 >1。CEA、CA199、CA12 5和CA15 3联合检测时敏感性、准确性及特异性均明显提高。其中CEA +CA199联合检测诊断癌性胸腔积液的敏感性为 92 .2 %

特异性为 90 .9%。结论 :肿瘤标志物CEA、CA199、CA12 5及CA15 3联合检测对癌性和结核性胸腔积液的鉴别诊断有较好的临床价值

联合方式以CEA +CA199为佳。

Abstract

Objective:To evaluate carcinoembryonic antigen(CEA)

carbobydrate antigen(CA199、CA125 and CA153) in differential diagnosis of cancer and tuberctulous pleural effusion.Methods:The serum and pleural fluid levels of 4 tmnor markers in 64 patients with cancerous effusion

44 patients with tuberculous effusion and 20 normal subjects were measured using immunoradiometric assay.Results:The serum and pleural fluid levels of CEA

CA199

CA125 and CA153 in the patients with cancerous effusion were significantly higher than in those with tuberculous effusion with a ratio>1.Assessing CEA

CA199

CA125

CA153 could significantly increase the sensitivity and specificity.The sensitivity of combined assay with serum CEA+CA199 in diagnosing malignant pleural effusion was 92.2%

and the specificity was 90.9%.Conclusion:Tumor markers of CEA

CA199

CA125 and CA153 have high clinical values in differential diagnosis of cancerous and tuberculous pleural effusion.The combined assay with CEA+CA199 should be recommended.

关键词

胸腔积液癌胚抗原糖类抗原鉴别

Keywords

pleural effusioncarcinoembryonic antigenCarbohydrate antigenIdentification

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