CAO Weixi, et al. Effect of TSPG on apoptosis of K562 cells and the expression of Fas,sfas[J]. Journal of Chongqing Medical University, 2004,(6):774-776.
CAO Weixi, et al. Effect of TSPG on apoptosis of K562 cells and the expression of Fas,sfas[J]. Journal of Chongqing Medical University, 2004,(6):774-776. DOI: 10.13406/j.cnki.cyxb.2004.06.020.
Objective:Our purpose is to clarify the mechanisms for total saponins of Panax ginseng(TSPG) inducing K562 cells to apoptosis.Methods:By using morphological observation and TUNEL
the effect of TSPG on apoptosis of K562 cells were studied.The expression of Fas was studied by immunocytochemistry
and sfas was assayed by ELISA.Results:The results indicated that 50
100μg/ml TSPG could induce K562 cells to apoptosis.Our experiment also showed after induced by TSPG
the ratio of positive K562 cells of expression Fas is increased ( P <0.01)
while sfas had no change.Conclusion:The mechanisms for TSPG inducing K562 cells to apoptosis may be related to the increased expression of Fas in K562 cells.