Objective:To investigate the effect of liver ultrasonography and the security to rabbits with hydrogen peroxide(H 2O 2) affused by rectum.Methods:48 rabbits were divided into 4 groups according to different H 2O 2 concentrations

and each group was divided into 4 groups according to different H 2O 2 dosages. Each rabbit was affused with H 2O 2 by rectum

then the effect of liver ultrasonography was observed

and the damages to the tissues of rabbits were pathologically checked.Results:The liver structure could be clearly developed with 1% H 2O 2 10ml affused

and the liver gray value increased with the H 2O 2 concentration increased.The time from affusion to develop was shortened and the duration of high echo was prolonged.But at same H 2O 2 concentration

the time to develop was not significantly different with the H 2O 2 dosage increased

and the high echo was decreased more slowly.The average survival time of rabbits was significantly negatively correlated to the H 2O 2 concentration(γ=-0.99)

while the damage degree was significantly positively correlated (γ=+0.99).Conclusion:H 2O 2 affusion can induce damage to tissues and microcirculation

while produce better liver ultrasound image

so it is important to chose suitable H 2O 2 concentration and dosage

to extend its clinical application.