Objective:To analyze the risk factors

clinical characteristics and pathogenesis in chronic obstructive pulmonary disease(COPD) complicated with ventilator-associated pneumonia(VAP) after mechanical ventilation.Methods:Retrospective analysis was performed on 122 cases of COPD complicated with VAP after mechanical ventilation for the clinical characteristics

bacterial culture and antibiotics sensitivity.These cases were divided into two groups with or without VAP.Results:The patient with COPD complicated with VAP often had no typical clinical presentation.Etiological microorganisms were predominated by Gram-negative bacterium.Mixed infections were common.Bacteria were often resistant to varieties of antibiotics.The incidence of VAP was 55.8%.Nutrition

complication

duration of mechanical ventilation

duration of antibiotics and steroid were related to the development of VAP.Conclusion:COPD complicated with VAP often has no typical clinical presentation.Development of VAP is associated with multiple predisposing factors.Etiological microorganisms are complex and often resistant to varieties of antibiotics.The combination of multidiscinplary therapy is necessary for prophylaxis and treatment of VAP.