Objective:To study the insulin resistance after traumatic brain injury in rats.Methods:Based upon the Feeney’s model

the blood glucose and insulin concentration of each animal group were measured 1/2 hour before injury and 6

12

24

48

72

120 hours after injury;the three indices BG

60-120

GIR

60-120

ISI reflecting the insulin sensitivity were measured 24 hours after severe traumatic brain injury by euglycemic-hyperinsulinemic clamp technique.Results:Both the blood glucose and insulin concentration increased markedly in medium and severely injured group after injury.BG

60-120

increased markedly and GIR

60-120

ISI decreased significantly 24 hours after severe trauma in injured animal compared with sham group.Conclusion:Both the blood glucose and insulin concentration increase markedly in severe injured group after injury.The fact that higher-level insulin cannot reduce the increased blood glucose is due to acute insulin resistance developing after traumatic brain injury.