WANG Zhihong, et al. Experimental study on hydroxychloroquine raised insulin sensitivity in insulin resistance rat models[J]. Journal of Chongqing Medical University, 2004,(4):429-432.
WANG Zhihong, et al. Experimental study on hydroxychloroquine raised insulin sensitivity in insulin resistance rat models[J]. Journal of Chongqing Medical University, 2004,(4):429-432. DOI: 10.13406/j.cnki.cyxb.2004.04.007.
Objective:To observe the effects of hydroxychloroquine on insulin sensitivity in high-fat feeding rats.Methods:After administrating hydroxychloroquine
the glucose infusion rate (GIR) determined by euglycemic clamp was used to measure the insulin sensitivity
and determining fasting plasma glucose
lipid and insulin.Results:(1)In high-fat feeding rats
the GIR60-120 was lower and the fasting plasma glucose
insulin
lipid levels were higher than those in normal feeding rats.(2)Hydroxychloroquine
rosiglitazone and metformin increased insulin sensitivity (the value of GIR60-120 was 9.3±1.2
11.6±1.4 and 9.8±1.3 mg.kg/min
respectively) in insulin resistance (IR) models.Moreover
the fasting glucose and some plasma lipid indices were improved in the IR rats with hydroxychloroquine administration.Conclusion:It is indicated that hydroxychloroquine could raise insulin sensitivity of IR rats with high-fat feeding
which was similar to metfomin but lower than rosiglitazone.In addition
hydroxychloroquine also could improve the glucose and blood lipid of the IR rats in some extent.