XIAN Ying, et al. Relationship between idiopathic thrombocytopenic purpura and virus infection in children[J]. Journal of Chongqing Medical University, 2004,(3):375-376.
XIAN Ying, et al. Relationship between idiopathic thrombocytopenic purpura and virus infection in children[J]. Journal of Chongqing Medical University, 2004,(3):375-376. DOI: 10.13406/j.cnki.cyxb.2004.03.040.
Objective:To study the relationship between idiopathic thrombocytopenic purpura (ITP) and various virus infections in children.Methods:The human parvovirusB 19(HPV-B 19)
Epstein-Barr virus(EBV)
Cytomegalovirus and Coxsackie virus (CBV 1-6) were detected using ELISA test in 102 patients with ITP.Results:The HPVB-19 IgM was positive in 41 patients(40.12%).CBV1-6 IgM was positive in 28 patients(27.45%).The CMV IgM was positive in 17 patients(16.66%).The EBV IgM was positive in 7 patients(6.86% ).The total rate of these four viruses was 50.98% of the patients with ITP observed in this study.Except EBV
the virus infections positive rate in this study were significantly higher than that of control group.( P <0.05).Conclusion:(1)These results suggest that the pathogenesis of ITP in childhood might be correlated with virus infections.(2)HPV-B19 infecteion is the most common virus in the patients with ITP.(3)The CMV infection is associated with the treatment effect and prognosis clinically in infant with ITP.(4)The CBV1-6 infection may be one of the virus caused ITP.