狼疮肾炎患者尿NAG、FDP检测的意义

肖刚; 甘华; 杜晓刚; 谯林; 刘渝梅

doi:10.13406/j.cnki.cyxb.2004.03.030

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狼疮肾炎患者尿NAG、FDP检测的意义

更新时间：2024-01-17

- 狼疮肾炎患者尿NAG、FDP检测的意义
- Determination of NAG and FDP in patients with lupus nephritis
- 重庆医科大学学报 2004年第3期页码：348-350
- 作者机构：
  
  1. 重庆医科大学临床学院肾内科
  2. 重庆医科大学临床学院肾内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.03.030
  中图分类号： R593.24
- 纸质出版日期：2004，
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[1]肖刚,甘华,杜晓刚,谯林,刘渝梅.狼疮肾炎患者尿NAG、FDP检测的意义[J].重庆医科大学学报,2004(03):348-350.

XIAO Gang, et al. Determination of NAG and FDP in patients with lupus nephritis[J]. Journal of Chongqing Medical University, 2004,(3):348-350.
[1]肖刚,甘华,杜晓刚,谯林,刘渝梅.狼疮肾炎患者尿NAG、FDP检测的意义[J].重庆医科大学学报,2004(03):348-350. DOI： 10.13406/j.cnki.cyxb.2004.03.030.

XIAO Gang, et al. Determination of NAG and FDP in patients with lupus nephritis[J]. Journal of Chongqing Medical University, 2004,(3):348-350. DOI： 10.13406/j.cnki.cyxb.2004.03.030.

摘要

目的 :探讨狼疮肾炎患者尿N -乙酰 - β -D -氨基葡萄糖苷酶（NAG）、纤维蛋白降解产物（FDP）的变化及意义。方法 :应用自动化生化分析仪、硝基苯酚比色法和乳胶凝集法分别检测 36例狼疮肾炎和 2 0例健康对照者尿NAG、FDP及血肌酐水平。结果 :狼疮肾炎患者肾功能正常组尿NAG水平较正常对照组明显升高（P <0 .0 1）

狼疮肾炎患者肾功能不全组尿NAG水平较肾功能正常组明显增高（P <0 .0 1） ;而且尿FDP阳性组的患者尿NAG升高更明显。结论 :狼疮肾炎患者肾小管间质损害在肾功能正常时已发生

伴肾小球内高凝血状态时

小管病变加重

Abstract

Objective:To determine urinary N-acetyl-beta-d-glucosaminidase (NAG) and products of fibrin degradation (FDP) in patients with lupus nephritis and to discuss its significance.Methods:We measured the levels of urinary NAG

FDP in 36 cases of patients with lupus nephritis and 20 cases in the control group using auto-biochemical-analyzer

colorimetry and latex coagulation test.Results:The levels of urinary NAG

FDP in patients with lupus nephritis with normal renal function were significantly higher than those in the control group.The levels of urinary NAG

FDP in patients with lupus nephritis with abnormal renal function were significantly higher than those normal ones.The levels of urinary NAG with lupus nephritis were significantly higher than those with negative FDP in the urine.Conclusion:The change of urinary NAG in the lupus nephritis patients suggests that the damage in renal tubular interstitum has taken place in LN patients when they are on the renal sufficiency stage.With the development of the coagulation in the glomeruli

the degree of renal tubular interstitum damage in LN also increases.

关键词

狼疮肾炎N-乙酰-β-D-氨基葡萄糖苷酶纤维蛋白降解产物

Keywords

lupus nephritisN-acetyl-beta-d-glucosaminidaseProducts of fibrin degradation

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