HPLC检测489例血清25OHD<sub>3</sub>结果分析

瞿平; 刘友学; 黎海芪; 李廷玉

doi:10.13406/j.cnki.cyxb.2004.02.035

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HPLC检测489例血清25OHD₃结果分析

更新时间：2024-01-17

- HPLC检测489例血清25OHD₃结果分析
- Serum levels of 25OHD₃ in 489 child patients measured by reversed-phase HPLC
- 重庆医科大学学报 2004年第2期页码：231-233
- 作者机构：
  
  1. 重庆医科大学儿科学院中心实验室
  2. 重庆医科大学儿科学院中心实验室,重庆,400014
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.02.035
  中图分类号： R446.1
- 纸质出版日期：2004，
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[1]瞿平,刘友学,黎海芪,李廷玉.HPLC检测489例血清25OHD_3结果分析[J].重庆医科大学学报,2004(02):231-233.

QU Ping, et al. Serum levels of 25OHD₃ in 489 child patients measured by reversed-phase HPLC[J]. Journal of Chongqing Medical University, 2004,(2):231-233.
[1]瞿平,刘友学,黎海芪,李廷玉.HPLC检测489例血清25OHD_3结果分析[J].重庆医科大学学报,2004(02):231-233. DOI： 10.13406/j.cnki.cyxb.2004.02.035.

QU Ping, et al. Serum levels of 25OHD₃ in 489 child patients measured by reversed-phase HPLC[J]. Journal of Chongqing Medical University, 2004,(2):231-233. DOI： 10.13406/j.cnki.cyxb.2004.02.035.

摘要

目的 :为了解患病儿童 2 5OHD3 状况。方法 :本文分析了我院 1994至 2 0 0 1年期间检测的 4 89例血清 2 5OHD3 结果。结果 :1、血清 2 5OHD3 高于正常参考值的检出率为 30 .6 7% （ 15 0 / 4 89） ;血清 2 5OHD3 低于正常参考值的检出率为 2 3.31%（ 114 / 4 89）。 2、患儿来源分析显示 :儿童保健科占 6 2 .17% （ 30 4 / 4 89）。 3、疾病与血清 2 5OHD3 状况分析显示 :临床诊断怀疑为维生素D（VD）中毒的 131例患儿其血清 2 5OHD3 检查结果高于正常参考值的占 77.86 % （ 10 2 / 131） ;临床诊断怀疑为维生素D（VD）缺乏的 118例患儿血清 2 5OHD3 检查结果低于正常参考值的占 37.2 9% （ 4 4 / 118）。提示临床上诊断VD缺乏与实验室检查的符合率明显偏低

临床上诊断VD缺乏的方法有待进一步完善。骨折患儿中有 10 .34% （ 3/ 2 9）的血清 2 5OHD3 水平低于正常参考值

其低水平的 2 5OHD3 不利于骨折的愈合。结论 :佝偻病是儿童保健预防的常见病之一

在预防的同时应避免发生超量使用VD导致中毒

本文分析显示有近 1/ 3（ 30 .70 % ）的患儿是因VD使用不当而导致中毒应当引起重视

Abstract

Objective:To analyze the serum levels of 25OHD 3 in children.Methods:489 children who visited the Children’s Hospital of Chongqing University Medical Sciences during 1994 to 2001 were included in the analysis.Serum level of 25OHD 3 was measured for each child by reversed-phase HPLC method

which was developed in our laboratory in early 1990s.Results:Of the 489 children

boys 287(58.69%) and girls 202(41.31%).30.67(150/489) children had serum level of 25OHD 3 above the normal range in this laboratory.23.31%(114/489) children had a serum 25OHD 3 below the normal range.The majority came from the Department of Primary Child Care of this hospital.77.86%(102/131) children clinically diagnosed as hypervitamin D were proved by our 25OHD 3 measurement

while only 37.29%(44/118) children clinically diagnosed as vitamin D deficiency had their serum 25OHD 3 below the normal range.In bone fracture patients

10.34%(3/29) children were found to be at lower level of serum 25OHD 3.Conclusion:Pediatricians should realize the possibility of herpervitamin D caused by incorrect treatment of rickets.The diagnosis of rickets

i.e.vitamin D deficiency

could not be just based on its clinical manifestations.25OHD 3 measured by HPLC is important for making correct diagnosis.

关键词

血清25OHD3水平HPLC儿童

Keywords

Child25OHD 3HPLC

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HPLC检测489例血清25OHD3结果分析

Serum levels of 25OHD3 in 489 child patients measured by reversed-phase HPLC

DOI：10.13406/j.cnki.cyxb.2004.02.035

摘要

Abstract

关键词

Keywords

references

HPLC检测489例血清25OHD₃结果分析

Serum levels of 25OHD₃ in 489 child patients measured by reversed-phase HPLC