TANG Hua et, al. Expression of TGF-β1 protein and its significance in colorectal carcinoma tissues[J]. Journal of Chongqing Medical University, 2004,(1):71-73.
TANG Hua et, al. Expression of TGF-β1 protein and its significance in colorectal carcinoma tissues[J]. Journal of Chongqing Medical University, 2004,(1):71-73. DOI: 10.13406/j.cnki.cyxb.2004.01.022.
Objective:To investigate the expression of TGF-β1 and its clinical significance in colorectal carcinoma(CRC).Methods:The expression of TGF-β1 in seventy patients with CRC and 10 normal colorectal mucosal tissues were examined by immunohistochemistry
and the expression of TGF-β1 was analyzed with relation to clinicopathologic factors and post-operative survival.Results:Compared with the normal colorectal mucosal tissues
the expression of TGF-β1 in CRC was higher.The overexpression of TGF-β1 is associated with lymph node metastasis
Dukes staging and poor prognosis in patients with CRC.Conclusion:TGF-β1 stimulates CRC cells infiltration and metastasis.The expression of TGF-β1 appears to be a new prognostic factor for the prediction of outcome in patients with CRC.