Objective:To explore the changes in rabbit endothelin-1 induced by alcoholism.Methods:24 rabbits were chosen and divided into two groups randomly.In experimental group wine containing 50% of alcohol at dosage of 8mL/(kg·d) was given

and the same dose of NS for controls by pouring into stomach with a plastic tube for 6 months and to observe the changes of ET-1

superoxide dismutase(SOD)

malondialdehyde(MDA) in plasma in 1-6 months.Results:In 1-3 months

the content of ET-1 and MDA did not change significantly (P>0.05)

but it increased gradually in 4～6 months (at 4 month P<0.05

at 5

6monthP<0.01).The content of ET-1 in the experimental group was positively correlated to MDA(r=0.64

P<0.01).The activity of SOD did not change remarkably in 1～2 month(P>0.05)

but it decreased gradually in 3～6 month(3

4month P<0.05

5、6month P<0.01).The content of ET-1 in the experimental group was negatively correlated to the activity of SOD (r=-0.24

P<0.05).Conclusion:Long-term excessive intake of wine increase oxygen-derived free radicals and ET-1

and lead to injury of endothelium of blood vessel

which may play a key role in the process of pathogenesis in alcoholism.