Objective: To investigate the expression of PPARα

PPARγ and NFκB in the aortic endothelial cells of the normal and hyperlipidemic rats and the change of IL-6 with the treatment of fibrates in vivo.Methods:The hyperlipidemic rat was established by feeding the high cholesterol food.The expressions of PPARα

PPARγ

NFκB and IL-6 in endothelial cells located in the aorta were presented by immunohistochemistry.The alteration among the PPARα

PPARγ and IL-6 in the hyperlipidemic rat with the treatment of gemfibrate and bezafibrate was observed.Results:There was a weak expression of PPARα

PPARγ

NFκB and IL-6 in the normal rat aorta endothelial cells

which were all enhanced in the hyperlipidemic rat.NFκB was drastically presented.After the treatment of gemfibrate and bezafibrate the expression of PPARα increased

while that of IL-6 decreased relatively

but NFκB expression was not directly influenced.Conclusion:The expressions of PPARs and NFκB increased in hyperlipidemic rats.Fibrates may relieve the secretion of inflammation factors in vivo to some degree through the activation of PPARs.